A Pilot Study into the Removal of Blood Clots using tPA Delivered Locally through the ‘GP’ Mechanical Thrombectomy Device

By Gillian Pearce, Neil Perkinson, Lee Brooker and Julian Wong.

Published by The Technology Collection

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Article: Print $US10.00
Article: Electronic $US5.00

We present data concerning the use of tPA with our recently invented thrombus aspiration device as a means of extracting blood clots in in-vitro experiments.
We also remove the blood clots using the aspiration device alone. Our esults are compared.

Background
There are approximately 130,000 strokes in the UK alone each year. More recent treatments have included use of thrombolytic agents such as alteplase, and mechanical clot removal devices. In our paper, we present results based on investigating using one such mechanical thrombectomy device (the GP mechanical thrombectomy device) with alteplase delivered locally through the device.

Method
Abattoir porcine blood clots are exposed to alteplase delivered through the GP device which is left in situ for a given time. The blood clot is then removed by applying vacuum suction through the device. We investigate the variation with clot removal pressures, times and volumes of fluid removed when alteplase of different concentrations are used. The results are compared to using a catheter without the GP device.

Results
The most effective clot removal was found when the GP device is used with alteplase, Less pressure was needed to remove the clot with the device compared to without the device (i.e. arterial catheter alone). The GP Mechanical Thrombectomy Device removes clot more efficiently than using the arterial catheter alone with or without concurrent use of alteplase. The results also showed that the smaller the diameter of the device the greater the pressure needed to remove the clot, and the larger the clot the larger the pressure and the extraction time.

Conclusion
Our experiments demonstrated overall that the use of alteplase with theGP clot removal device is highly effective in removing clots, and is worthy of further investigation.

Keywords: tPA, Thrombus Aspiration Device, Stroke, Clot Removal

International Journal of Technology, Knowledge and Society, Volume 7, Issue 1, pp.107-114. Article: Print (Spiral Bound). Article: Electronic (PDF File; 832.721KB).

Dr. Gillian Pearce

Senior Lecturer in Clinical Physiology and Anatomy, Biomedical Sciences Division, University of Wolverhampton, Wolverhampton, West Mid, UK

Following her Ph.D on Supernovae, Dr Pearce undertook post-doctoral research in the fields of (i) Supernovae and (ii) Solar Astrophysics. She then completed a medical degree at Oxford University and practised in the NHS for several years in the field of orthopaedics. She has undertaken research into (i) pulsars (ii) space medicine and (iii) medical inventions including Orthopaedic devices for use in theatre, a device for assisting the partially sighted, a technique for imaging plaques in arteries and a blood clot removal device for use in thromboembolic strokes. Dr Pearce is also a senior lecturer in clinical physiology and anatomy. She was a short-listed astronaut candidate for the JUNO Space mission.

Neil Perkinson

Priest, Whangamata Community Church, Waikato, Whangamata, New Zealand

Lee Brooker

Student, Wolverhampton University, Wolverhampton, West Midlands, UK

Lee Brooker completed a B.Sc (hins) degree in Biomedical Sciences at Wolverhampton University, UK. he also completed a M.Sc in biomedical aciences, worked in a lab and is now studying for a MPharh degree.

Julian Wong

Vascular Surgeon, North Staffs Royal Infirmary, Stoke on Trent, UK

Julian Wong is a vascular surgeon who is interested in the development of new medical devices for use in vascular surgery.

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